TF and Miyoshi myopathy: Deregulation of TFs contributes to MM pathogenesis through: (1) direct TF modifications (e.g., mutations); (2) intrinsic genetic alterations or extrinsic stimuli within the BM microenvironment that trigger signaling pathway-mediated TF activation or inhibition; (3) epigenetic changes in DNA methylation, histone modifications and non-coding RNAs; and (4) TF dependency on prolonged oncogene activity (“oncogenic addiction”) [11,18,19,20,21,22].