Continuing basic and translational research on AP-1 TFs utilizing new technologies such as NMR-based screens, differential scanning fluorimetry (DSF), in silico 3D modelling, as well as Slim-seq will be fundamental to further advance our insights on the complex function of this TF family, facilitating the identification of valuable targets and the development of derived innovative therapies for MM to once more improve patient outcome. The gene discussed is FOSB; the disease is Miyoshi myopathy.