In bortezomib-exposed hepatoma cells, we found that TRIB3 resides predominantly at genomic regions containing the C/EBP–ATF motif, which we and others have previously described as the regulatory motif mediating the upregulation of a number of ATF4 target genes in response to cellular stress [12,13,45,51,52]. Here, ATF4 is linked to hepatocellular carcinoma.