STAT3 and colorectal cancer: To determine whether our findings are relevant in other cancers, we performed GSEA using 592 colorectal cancer patient data as they frequently express oncogenic NTRK1 fusions [36] and found significant enrichment of STAT3 activation gene signature in patients with high NTRK1 mRNA levels (Supplementary Figure S2), suggesting that the signaling crosstalk may also be found in other malignant tissues.