However, our data suggested there is a marked association between TRIP13 expression and CD8+/Treg ratio in LGG and GBM, but neither differ between other immune cell type ratio (such as M1/M2 ratio), implying that multiple immune activated and suppressive mechanisms may be involved in the tumor microenvironment, and it is unlikely caused by differences in levels of individual genetic factor. This evidence concerns the gene TRIP13 and glioblastoma.