CD8A and glioblastoma: Both in LGG and GBM samples, striking differences were observed among in high TRIP13 level tumors; the ratio between mRNA levels of CD8+ T cell–specific genes (n = 13) to regulatory T (Treg)-specific genes (n = 13) was notably reduced, compared to low TRIP13 level tumors (Figure 11A,B, Table S7).