For GBM, we observed that DNA methylation in its promoter region near the first exon of 5′ untranslated region (5′ UTR) was positively related to TRIP13 expression (Figure 8Ab, r = 0.261, p < 0.05), which suggested that diverse genomic regions of DNA methylation may be differentially involved in regulating TRIP13 expression in glioma. This evidence concerns the gene TRIP13 and central nervous system cancer.