The other exception is the SAM pointed domain-containing ETS transcription factor (SPDEF), the only member of the PDEF subfamily, whose anti-metastatic and anti-tumorigenic activities in PCa and hepatocellular carcinoma cells respectively are antagonised by UPS processing following phosphorylation by CDK11B [107,108]. The gene discussed is CDK11B; the disease is hepatocellular carcinoma.