However, the beneficial or detrimental consequences of deregulated GH secretion on dento-alveolar complex are controversial, as reported recently for acromegaly, which does not appear to induce generalized hypertrophy of the gingiva or hypercementosis, but could protect from a severe periodontal disease by conferring more robust periodontal tissues [10,13] due to an increase in the levels of protective molecules such as bone morphogenetic protein 2 (BMP2) [14]. The gene discussed is BMP2; the disease is periodontal disorder.