IGF1 differentiating effects reported in dental pulp cells differentiation (DPCs and DPSCs) and SCAPs [66,68] make it a bioactive molecule worthy of interest for future innovative therapeutics for dentin lesion repair in adult or forming teeth, therefore allowing the tooth preservation instead of its removal in various pathological situations, including tooth decay, fracture, or infection. The gene discussed is IGF1; the disease is infection.