Namely, activated NK cells usually produce interferon γ (IFN-γ) and granulocyte–macrophage colony-stimulating factor (GM-CSF), whereas the CRS induced by CAR-T cells is mainly mediated by pro-inflammatory cytokines, such as IL-6, IL-1, and tumor necrosis factor α (TNF-α) [88]. Here, TNF is linked to congenital rubella syndrome.