The role of this couple of enzymes was strongly matched to irreversible cardiac remodeling due to either the activation (when acetylated) or depletion (when deacetylated) of GATA Binding Protein 4 (GATA4) and Myocyte Enhancer binding Factor 2 (MEF2), transcription factors responsible for the gene expression rewiring during cardiac hypertrophy [193,194,195]. The gene discussed is GATA4; the disease is cardiac hypertrophy.