CXCR2 and neoplasm: On the other hand, the presence of a high number of CXCR2 cells in tumors characterized by high expression of PD-L1 on both tumor and stromal cells, but also in tumors exhibiting high level of PD-1, could represent an attempt of the immune cells to counteract the immune escape that is promoted by the PD1/PD-L1 pathway.