A screen of five metabolic enzymes found to be affected by SHetA2 in other cancers, demonstrated that SHetA2 reduced mortalin co-immunoprecipitation of aldehyde dehydrogenase 18 family member A1 (ALDH18A1), cytidine triphosphate synthetase (CTPS), malate dehydrogenase (MDH1), and enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, (ECHS1) in Ishikawa cells (Figure 4A). This evidence concerns the gene PHGDH and cancer.