CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome: In particular germline alterations of the E-cadherin gene, CDH1, occur in about 40% of all HDGC cases screened [2], with an estimated lifetime risk of diffuse gastric cancer (DGC) of 70% in men and 56% in women, and a cumulative incidence of LBC in women of around 42% [3].