The major findings of this study were the following: (a) CDH1 germline mutations excluding GC are found predominantly BC (60% of all non-GC cancers); (b) the mean age at diagnosis was higher in the non-GC cancer (50.6 year), compared to GC (40.6 year); (c) the majority of mutations were localized in the cytoplasmic domain (Figure 2). The gene discussed is CDH1; the disease is cancer.