Given the strongest association of the total AKT expression out of all investigated candidates with poor features of PeCa in the current analysis and evidence for its crucial role in adverse tumor behavior for other human cancers, we tested the potential of AKT inhibition to exert antitumor properties in our two primarily established PeCa cell lines UKF-PeC-3 and UKF-PeC-4. This evidence concerns the gene AKT1 and neoplasm.