Most recently, the efficacy of capivasertib was assessed in the nonrandomized phase 2 trial entitled NCI-MATCH, which enrolled patients with AKT1 E17K-mutated metastatic tumors of different origin that either had progressed after at least one line of standard systemic treatment or for which no effective therapy exists [40]. The gene discussed is AKT1; the disease is metastatic neoplasm.