STAT3 and ductal breast carcinoma in situ: Our previous observation of an association of Sdc-1 with angiogenic factors in ductal carcinoma in situ of the breast is in line with this idea [16], as are our previous studies demonstrating altered signaling through the MAPK, Notch, Wnt, and IL-6-STAT3-pathways in Sdc-1-depleted cells as a mechanistic element of aberrant cytokine and angiogenic factor expression [9,14,23,73,74].