It has been shown that SARS-CoV-2 can infect and replicate in human pancreatic islets, in association with reduced insulin-secreting granules in pancreatic β-cells and impaired glucose-stimulated insulin secretion [65], which may explain the deterioration of glycemic control observed in diabetic patients with COVID-19 necessitating exceptionally high doses of insulin [66], but also increase the risk for onset of diabetes after COVID-19 [67]. This evidence concerns the gene INS and COVID-19.