In addition to AS of RPS6KB1 mentioned above, this includes, e.g., AS of MKNK2 to produce an oncogenic isoform of this kinase; AS of INSR to produce a mitogenic isoform of the insulin receptor; and AS of BIN to produce a variant with lost ability to bind MYC and thus with lost tumor suppressor activity [231,235]. Here, RPS6KB1 is linked to neoplasm.