SRSF2 and acute myeloid leukemia: Interestingly, when a panel of 45 drugs targeting spliceosome components and epigenetic regulatory proteins was tested in a cell viability screen on an isogenic pair of AML cell lines with wild type and mutant SRSF2, the SRSF2 mutant cells were particularly sensitive to the SF3B1 inhibitor E7107, the PRMT5 inhibitor EPZ015866 and the PRMT1/3/4/6 inhibitor MS023 [392].