BCL2 and neuroblastoma: In a synthetic lethal screen with siRNAs targeting proteins with deubiquitinase or ubiquitinin-like motifs, PRPF8 and the complex B-associated protein ubiquitin-like protein 5 (UBL5) were found to promote resistance to Bcl-2 inhibitor ABT-737 in neuroblastoma cells, through AS of induced myeloid leukemia cell differentiation protein MCL1 into an anti-apoptotic short transcript variant.