Silencing SF3B1 or SF3A1 reduced EWS-FLI1 protein activity and Ewing sarcoma cell survival; and inhibition of SF3B1 with a small molecule resulted in mis-splicing of EWS-FLI1 and loss of Ewing sarcoma cell viability [270]. The gene discussed is EWSR1; the disease is Ewing sarcoma.