Moreover, magnolol suppresses GBM cell migration by regulating focal adhesions and N-cadherin, while gamabufotalin demonstrates antimetastatic effects by downregulating urokinase plasminogen activator (uPA) and carbonic anhydrase 9 (CA9) and upregulating tissue inhibitor of metalloproteinases 3 (TIMP-3) [71,72]. This evidence concerns the gene CA9 and glioblastoma.