TP53 and neoplasm: Differentiated models have been developed considering the side of cancer origin (fallopian tube vs. ovarian surface epithelium) as well as tumor genetics targeting critically involved genes (like Trp53, Rb1, Pten or Dicer1) and signaling pathways (like PI3K, Myk, PTEN or Wnt/β-catenin) [322,323,324,325,326,327].