In colorectal carcinomas, PLK2 exerts tumor growth-promoting and apoptosis-inhibiting effects [167,175,177,178] as is the case for several other tumors like lung cancer, cholangiocarcinoma, osteosarcoma, and head and neck carcinoma [66,155,179,180,181,182]. The gene discussed is PLK2; the disease is cholangiocarcinoma.