It was shown that serum quantification of ATP binding cassette subfamily A member 13 (ABCA13), secreted acidic and cysteine rich protein (SPARC) and matrix metallopeptidase 8 (MMP8) by ELISA has the potential to be used as a diagnostic tool for PTB, greatly improving early detection of MAP latent infections, which are currently escaping detection with conventional diagnostic methods [32]. Here, MMP8 is linked to disease arising from reactivation of latent virus.