Since the response to TGFβ ligand in RDEB SCC keratinocytes in culture is heterogeneous [91], which is similar to most other cancers studied in the context of TGFβ [92], it is more likely that the primary driving role of TGFβ in SCC is within the tumor microenvironment, affecting cancer-associated fibroblasts, immune cells, and other components, rather than a direct role on the tumor keratinocytes themselves. Here, TGFB1 is linked to neoplasm.