Animal models of tissue damage-driven cancer identify innate immunity as a potential driver, and a connection between wound healing and tumor formation has been identified in high-mobility group box 1 (HMGB1) [53], a protein derived from keratinocytes that activate inflammation and have been used to induce homing of specific subsets of bone marrow-derived pre-cursors [54]. Here, HMGB1 is linked to neoplasm.