PRKN and liver cancer: Among them, artemisinin regulates mitochondrial membrane permeability, promotes cytochrome C release, induces overproduction of ROS by mediating the PINK1–Parkin pathway, and shows selective anticancer properties in cervical, colon, and breast cancer cells [27]; by binding to the GPR30 receptor and regulating the mitochondrial fission process, stephentanin hydrochloride induces PINK1–Parkin pathway-dependent mitochondrial autophagy and inhibits the proliferation of liver cancer cells [28].