Mitophagy is correlated with various cancer cell characteristics, including the promotion of ROS production, disrupting the redox balance [22], accelerating the mitochondrial unfolded protein response (UPRmt), increasing the production of unfolded proteins and toxic metabolites [23], increasing mitochondrial membrane permeability, promoting cytochrome C release into the cytoplasm to induce cell apoptosis [24], adjusting intracellular energy metabolism to cause drug resistance [25], and inducing mitochondrial DNA damage [26]. This evidence concerns the gene CYCS and cancer.