In addition, EZH2 knockdown decreased H3K27me3 levels on PTEN gene promoter and resulted in a significant increase in PTEN mRNA and protein expression in three human Ph+ cell lines, as well as in LSK (Lin−/Sca-1+/c-Kit+) cells from CML mice. The gene discussed is PTEN; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.