The two main features of PD include neuronal loss in specific areas of the substantia nigra and the widespread intracellular α-synuclein protein accumulation known as Lewy bodies; the dopaminergic depletion in the nigro-striatal pathway underlies the motor symptoms that characterize patients with PD, including bradykinesia, tremor, rigidity, balance and gait impairment [2,3]. Here, SNCA is linked to Parkinson disease.