The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved. Aberrations in FGFR2 have been seen to affect FGRFR2 signaling that has been recognized in breast cancer. Amplification of FGFR2 is present in 3.6% of triple-negative breast cancers (TNBCs) [64]. The gene discussed is FGFR2; the disease is triple-negative breast carcinoma.