MT-CO1 and cancer: Detected mutations, such as G5949A (G16X), T6124C (M74), C6924T (A341S), also concern highly conserved amino acids examined in an American population (482 men with prostate cancer and 189 men without cancer), where COI polymorphisms were detected in 8.8% of Caucasian patients with prostate cancer and in 72.8% of cancer patients of African ancestry [80].