The aim of our study was to evaluate PHD1, PHD2 and PHD3 mRNA expression levels in primary tumours and normal lung tissue of surgically resected NSCLC patients and to correlate their expression with selected regulators of HIF signalling and with clinicopathological characteristics and overall survival of NSCLC patients who were treated with radical surgery. This evidence concerns the gene EGLN3 and non-small cell lung carcinoma.