Feld J et al. reported a case of unprecedented concomitance of mixed AIHA and B-prolymphocytic leukemia (PLL) evolution in an elderly CLL patient treated with a combination of prednisone, idelalisib and rituximab, allowing normalization of Hb levels and white blood count within 2 months of therapy [20]. Here, GSTM1 is linked to B-cell chronic lymphocytic leukemia.