A recent study by Yang et al. [46] demonstrates that anti-TNF treatment prevents colonic inflammation and subsequent tumor development in both chemically-induced (DSS/ApcMin/+) and spontaneous (Il10−/− ApcMin/+) CAC models by modulating microbiota composition and transcription, while co-housing anti-TNF treated with control mice prevented these microbial change and inhibited the anti-tumor effects of TNF neutralization [38]. The gene discussed is IL10; the disease is neoplasm.