Bangladeshi strains exhibited other S protein mutations or variants, as well as combined variants, such as L5F, L18F, N354S, A520K, Q675H/R, P681H/R, L5F + D614G, and D614G + M1229Y, which have been previously linked with increased infectivity under experimental setups [8] and may have significant biological properties in response to natural infection. The gene discussed is PROS1; the disease is infection.