We also assessed the expression patterns of c-MYC oncogene and HMGA2 transcription factor in the organoid cultures, because of the important role of c-MYC oncogene in colon tumorigenesis [21] and the association of HMGA2 with the poor disease outcome and KLK6 overexpression in the CRC patients [22,23]. The gene discussed is HMGA2; the disease is colorectal carcinoma.