Would you have more confidence in that negative PSA density test result if 99% of similar patients in your practice who had a PSA density <0.08 ng/mL/cc actually did not turn out to have prostate cancer, or if 99% of similar patients who had a PSA density <0.08 ng/mL/cc actually did turn out to have clinically significant prostate cancer? The gene discussed is KLK3; the disease is prostate carcinoma.