Would you be more confident in that positive test result if only 1-in-1,000,000 similar patients in your practice who had a PSA density >0.08 ng/mL/cc turned out to truly have clinically significant prostate cancer, or if 999,999-in-1,000,000 similar patients who had a PSA density >0.08 ng/mL/cc turned out to truly have clinically significant prostate cancer? The gene discussed is KLK3; the disease is prostate carcinoma.