By repressing the expression of the EMT-TF Twist as well as increasing EpCAM and E-cadherin at the plasma membrane of CRC cells, BMAL1-KD promoted MET-like changes, supporting the conclusion that the circadian transcription factor BMAL1 plays a pivotal role in CRC metastasis progression, regulating the balance between EMT and MET. This evidence concerns the gene TWIST1 and colorectal carcinoma.