BMAL1 and colorectal carcinoma: To investigate BMAL1′s involvement in the EMT process and invasiveness during colorectal tumorigenesis, two primary CRC cell lines (i.e., HCT116 and SW480) and a metastatic cell line, SW620, were transduced with lentiviruses encoding a scrambled shRNA (shScr) or a shRNA-targeting BMAL1 (shBMAL1).