PRL and Anxiety: Besides showing that lower prolactin is associated with more severe anxiety symptoms, premature ejaculation and an adverse metabolic profile [87], we reported for the first time that low prolactin at baseline (I–IV quintile) is associated with forthcoming MACE, after adjustment for possible confounders (Figure 1C), and a 6% increase in risk for each 10 ng/mL of reduction in baseline prolactin was found [88].