In our studies, we evaluated the expression patterns of TrkB, H-, K-, and N-Ras (namely, pan-Ras) and all three isoforms of ShcA (p66Shc, p52Shc, and p46Shc) proteins in samples of brain tumors belonging to several subgroups (astrocytic, oligodendrioglial, ependymal, choroid plexus, and embryonal tumors) and defined malignancy grades (I, II, III, and IV) based on the 2016 WHO classification [45]. This evidence concerns the gene SHC1 and embryonal neoplasm.