CD47 and neoplasm: In mice bearing selected tumour types, AAC’s carrying TAA synthetic long peptides capable of interacting with and activating macrophages and DCs without modifying CD47 expression (a multifunctional cell surface protein that mediates inhibition of phagocytosis, T-cell activation and is a regulator of inflammation) resulted in antigen-specific CD8+ T-cell and mediated anti-tumour responses measured by the reduction of tumour size [211].