HIF1A and neoplasm: The major limitations to the use of HIF-1α inhibitors in patients are the high side-effect toxicity, due to the inhibition of the physiological functions of HIF-1α, and the limited anti-tumor efficacy, likely because several downstream effectors of HIF-1α become independent drivers of oncogenesis and progression (https://clinicaltrials.gov/ct2/results/details?cond=Cancer&term=HIF), accessed on April 2021.