SUCNR1 and neoplasm: Of note, SUCNR1 is highly expressed also in kidney cancer, where its signaling promotes angiogenesis, hematopoiesis and inflammation [39], and in tumor-associated macrophages (TAMs), where the binding of succinate favors the polarization toward a tumor-permissive M2-phenotype, facilitating cancer cell migration, invasion and metastasis [38].