Nonetheless, addition of tumor EVs enhanced MMT in such cells, as demonstrated by the increase in α-SMA expression in MC1 (Figure 5b), by the release of active MMP-2/MMP-9, particularly evident in MC2 and MC3, and by the activation of Smad2/3 shown in MC1 in Figure 5c, Figures S3b and S2b, and Tables S3 and S4. The gene discussed is SMAD2; the disease is neoplasm.