One patient with primary and four patients with secondary CNS lymphoma each received one intravenous infusion of CD19-directed (2.2 × 106 to 7.1 × 106/kg body weight) and one infusion of CD22-directed CAR T-cells (3.1 × 106 to 7.0 × 106/kg). The gene discussed is CD22; the disease is primary central nervous system lymphoma.