They then confirmed the involvement of GRP78 and the UPR in regulating the survival of mut-BRAF CRC cells by using HA15, a small molecule inhibitor against GRP78 that has been previously reported to display anti-cancerous activity on melanoma cells, including cells isolated from patients and cells that developed resistance to BRAF inhibitors, and other liquid and solid tumors. This evidence concerns the gene HSPA5 and melanoma.