For example, specific inhibition of the immunoproteasome subunit LMP7 (one of the subunits whose synthesis is specifically stimulated by pro-inflammatory cytokines, such as IFN-γ or TNF, leading to the formation of the immunoproteasome) has been shown to interfere with CRC development; in fact, treatment with the LMP7 inhibitor ONX 0914 blocked tumor initiation and progression in either chemically-induced (AOM/DSS) or transgenic mouse models (ApcMin/+) of colon carcinogenesis [115]. This evidence concerns the gene PSMB8 and colorectal carcinoma.