APC and colorectal carcinoma: Naik and colleagues, by using a siRNA library targeting 691 known and predicted human kinases, uncovered an unanticipated non-endothelial role of VEGFR1 in the survival of cells addicted to WNT/beta-catenin signaling and demonstrated that VEGFR1 blockade is synthetic lethal in CRC cells with APC mutations [59].