To identify direct BET-dependent target genes accounting for the increased sensitivity of CIMP+ colon cancer cells, four CIMP+ and two CIMP- CRC cell lines were profiled by RNA-seq, whereas ChIPseq was used to profile the genomic enrichment of lysine 27 acetylation of histone H3 (H3K27ac); this approach uncovered an enrichment of MYC pathway gene signatures in the CIMP+ cells. Here, DNER is linked to colonic neoplasm.