HNF4A and colorectal carcinoma: Using a different approach, Emami and colleagues used a report gene activation assay constituted by a luciferase gene under the control of several TCF binding sites expressed in CRC cells with deregulated beta-catenin activity, to screen a secondary structure templated small-molecule library of 5000 compounds for inhibitors of beta-catenin/TCF-mediated transcription.