BRD4 and carcinoma: McCleland and colleagues found that, whereas overall BRD4 levels remained unchanged at different stages of colonic tumorigenesis, the BRD4-LF isoform, which has been more strongly implicated in transcriptional regulation, was specifically upregulated during the premalignant-to-malignant transition (adenoma to carcinoma) and was highly expressed in CRC cell lines.