Pancreatitis risk increases approximately 60-fold by having the heterozygote genotype in SPINK1 and CFTR (one variant in one allele of SPINK1 and one variant in one allele of CFTR), whereas the CP risk increases up to 900-fold by having a CFTR compound heterozygote genotype (two heterogeneous variants) and the SPINK1 p.Asn34Ser variant in one allele [67,77]. Here, SPINK1 is linked to pancreatitis.