Indeed, NK cells are equipped with an array of germline-encoded activating receptors that cooperatively regulate their capability to discriminate between healthy and diseased cells [6,8,25,26,27,28,29,30]; NK cells’ ability to establish multiple activating interactions with mAb-opsonized tumor cells may amplify CD16-initiated functions, especially under conditions of suboptimal receptor aggregation. Here, FCGR3A is linked to neoplasm.