In addition, the C-type lectin CD94/NKG2C receptor complex and the members of the natural cytotoxicity receptor (NCR) family, i.e., NKp30, NKp44, and NKp46, induce activating signals in NK cells, upon binding to nonclassical HLA-E molecule or to still partially identified tumor-associated ligands, respectively [6,25,26,27,28,44,45,46,47,48,49]. This evidence concerns the gene NCR2 and neoplasm.