Indeed, intratumoral NK-derived cytokines and chemokines promote DC recruitment and survival at the tumor site [18,123,124]; moreover, NK cell-derived IFNγ efficiently promotes DC maturation (editing), which contributes to the development of a Th1-oriented response and amplifies the programming of CTL responses [18,40,125,126,127,128,129]. This evidence concerns the gene IFNG and neoplasm.