Indeed, through CD5 and TRPC1 silencing in pERK1/2+ B-CLL cells, IL-10 production is decreased, demonstrating that TRPC1 is involved in the production of anti-inflammatory cytokines, together with CD5 expression in a BCR-independent Ca2+-dependent way, promoting cell survival [50]. Here, CD5 is linked to B-cell chronic lymphocytic leukemia.