Moreover, CPS treatment suppressed significantly the expression of many key cell signalling pathways, in particular Kirsten rat sarcoma (KRAS), protein kinase B (AKT), GRB2-associated binding protein 2 (GAB2), protein tyrosine phosphatase non-receptor type 11 (PTPN11), rapidly accelerated fibrosarcoma B (BRAF), inositol polyphosphate-5-phosphatase D (INPP5D), and mitogen-activated protein kinase 7 (MAPK7) proteins [92]. This evidence concerns the gene PTPN11 and fibrosarcoma.