Consistent with previous reports, Jiang et al. showed that PD-L1 positivity was associated with more aggressive disease features, including deeper tumor invasion and more nodal metastases, ultimately leading to significantly shorter OS in patients with esophageal squamous cell carcinoma treated with definitive therapy, such as curative esophagectomy or definitive (chemo)radiation [102,103,104]. Here, CD274 is linked to neoplasm.