In multivariate analysis, mRNA expression in TFL was an independent prognostic factor for early HCC recurrence (hazard ratio (HR) 2.3 and 2.1, for the discovery and validation cohort respectively) and HCC-specific survival (HR 2.3 and 3.6, respectively) in both cohorts, as is shown in Table 2. The gene discussed is ZC3H12D; the disease is hepatocellular carcinoma.