Data from the clinical studies support the important role of FGF23/Klotho/Wnt pathway cross-talk, where it was shown that in patients on hemodialysis elevated serum FGF23 with lower sKlotho and sclerostin, may act as a predictor of CV complications (LVH, acute coronary syndrome, arrhythmias, etc.)[84]. This evidence concerns the gene FGF23 and acute coronary syndrome.