Mitochondrial dysfunction in NAFLD might represent another model to test the efficacy of TZDs and the role of novel drugs such as selective modulators of PPARα (pemafibrate and K-877), and PPARγ (INT-131), PPARδ (HPP-593), and PPARα/γ (DSP-8658) agonists [171]. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.