Despite all types of FFA may contribute to steatosis, saturated FFA are especially toxic [74], e.g., palmitic acid (C16:0) and stearic acid (C18:0) are more toxic than monounsaturated FFA (e.g., oleic acid, C18:1), which synthesis depends on the enzyme stearoyl-CoA desaturase [75], and contribute to reduced cell death via decreased levels of proapoptotic proteins (BIM (BCL2L11) and PUMA (BBC3)) while promoting the sequestration of palmitic acid in TG [76]. The gene discussed is BBC3; the disease is steatosis.