TNF and metabolic dysfunction-associated steatotic liver disease: Additional factors contributing to NAFLD include the environment, gut microbiome, deranged glucose-lipid metabolic pathways, metabolic inflammation primarily mediated by innate immune signaling, adipocytokine impairment (e.g., tumor necrosis factor (TNF)-α, adiponectin, resistin, leptin, angiotensin II), and comorbidities [2,3,4].