Therefore, we in the present study determined the role of DDR2 in LPA-induced ovarian cancer cell invasion, and found that LPA upregulates DDR2 expression through the HIF-1α/Twist1 signaling cascade to promote ovarian cancer cell invasion, expanding the underlying mechanism of LPA-induced ovarian cancer cell aggressiveness and providing potential biomarkers for ovarian cancer. This evidence concerns the gene TWIST1 and ovarian carcinoma.