GPT and HIV-1 infection: In the “Evaluate the safety tolerability and acceptability of long-acting injections of the HIV integrase inhibitor, GSK1265744, in HIV-uninfected men” (ECLAIR) trial, a phase 2a study assessing the safety, tolerability, and pharmacokinetics of long-acting cabotegravir versus a placebo in healthy men not at high risk of HIV-1 infection, one patient developed acute HIV-1 infection and had grade 3 elevations in ALT and grade 2 elevations in AST at week 53 [57].