GPT and HIV-1 infection: In the “Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection” (SPRING-2) trial, a phase 3 clinical trial that compared the efficacy and safety of dolutegravir versus raltegravir as first-line treatment for antiretroviral-naive adults, two patients receiving dolutegravir + emtricitabine/tenofovir disoproxil fumarate or abacavir/lamivudine developed increases in ALT at least five times ULN, requiring discontinuation, with one of those patients possibly developing a dolutegravir-induced liver injury with associated hypersensitivity [53].