The GS-236-0103 study compared elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus atazanavir/ritonavir+ emtricitabine/tenofovir disoproxil fumarate for initial treatment of HIV-1 infection and reported elevations in ALT of any grade (21.6% vs. 15.3%, respectively) [48]. The gene discussed is GPT; the disease is HIV-1 infection.