Here, using summary statistics from GWAS meta-analysis of severe COVID-19 combined with expression Quantitative Traits Loci (eQTLs), chromosome conformation capture (Hi-C) data, and whole exome sequencing (WES) data, we aimed at identifying causal genetic variants that can specifically affect CCR5 in order to understand the underlying mechanism of SARS-CoV-2 infection in patients with severe clinically manifestation of disease. Here, CCR5 is linked to COVID-19.