However, all the minor alleles were associated with increased risk of developing severe COVID-19 (rs9845542 P = 4.2 × 10−20, OR = 1.33, 95% CI: 1.25–1.41; rs12639314 P = 7.1 × 10−9, OR = 1.23, 95% CI: 1.14–1.31; rs35951367 P = 3.2 × 10−19, OR = 1.32, 95% CI: 1.24–1.40) (Supplementary Table S1) and correlated with lower expression levels of CCR5 in lung (Figure 2B). This evidence concerns the gene CCR5 and COVID-19.