CD22 and autoimmune disease: A synthetic mouse CD22 mimetic with low micromolar affinity, Neu5Gcα2-6Galβ1-4GlcNAc with a 9-N-biphenylacetyl group [64] (Table 2), was synthesized with a lipid aglycone and formulated into liposomes along with antigens related to the target autoimmune diseases, inducing tolerance in vivo.