PALB2 (Partner and Localizer of BRCA2) mediates the interaction between BRCA1 and BRCA2, plays a role in the nuclear localization of BRCA2, aids in RAD51 loading at resected DNA breaks, and pathogenic mutations in PALB2 have been found to predispose to breast, ovarian, and prostate cancer. The gene discussed is BRCA2; the disease is prostate cancer.